Article

Human and bats genome robustness under COSMIC mutational signatures

2024-09-07

Abstract excerpt

Carcinogenesis is an evolutionary process, and mutations can fix the selected phenotypes in selective microenvironments. Both normal and neoplastic cells are robust to the mutational stressors in the microenvironment to the extent that secure their fitness. To test the robustness of genes under a range of mutagens, we developed a sequential mutation simulator, Sinabro, to simulate single base substitution under a...

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Literature Corpus work: d861026f-c6be-559b-a300-def695d2c745
DOI: 10.1101/2024.09.05.611453

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