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Article

Linking somatic mutations in cancer to the electronic properties of DNA.

BMC genomics - 2 May 2026

de Witte Benoît, Karamaoun Cyril, Hermans Pauline, Tarabichi Maxime, Pucci Fabrizio, Rooman Marianne

Abstract excerpt

Oxidative stress, generated by both endogenous and exogenous agents, can cause DNA lesions that, if not repaired, accumulate as somatic mutations and can contribute to cancer initiation. Here, we explored this problem through the lens of DNA electronic properties, quantified by the vertical ionization potential (vIP) of nucleobase motifs, which reflects their susceptibility to oxidation. We analyzed genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42069548
DOI: 10.1186/s12864-026-12879-5
PMCID: PMC13289428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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