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Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes.

Molecular biology and evolution - 3 Feb 2025

Iliushchenko Dmitrii, Efimenko Bogdan, Mikhailova Alina G, Shamanskiy Victor, Saparbaev Murat K, Matkarimov Bakhyt T, Mazunin Ilya, Voronka Alexandr, Knorre Dmitry, Kunz Wolfram S, Kapranov Philipp, Denisov Stepan, Fellay Jacques, Khrapko Konstantin, Gunbin Konstantin, Popadin Konstantin

Abstract excerpt

Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive 192-component mtDNA mutational spectrum for chordates by analyzing 118,397 synonymous mutations in the CytB gene across 1,697 species and five classes. This analysis revealed three primary forces shaping mtDNA mutagenesis: (i)...

Read the complete abstract on PubMed

Topics

DNA, Mitochondrial
DNA Replication
Animals
Mutation
DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutagenesis

DNA Repair

DNA Polymerase gamma

Mitochondria

DNA Mismatch Repair

DNA-Directed DNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 39903101
DOI: 10.1093/molbev/msae261
PMCID: PMC11792237

Genes

POLG

Provenance

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