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EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2020

Ma Yiyi, Yu Lei, Olah Marta, Smith Rebecca, Oatman Stephanie R, Allen Mariet, Pishva Ehsan, Zhang Bin, Menon Vilas, Ertekin-Taner Nilüfer, Lunnon Katie, Bennett David A, Klein Hans-Ulrich, De Jager Philip L

Abstract excerpt

Not all APOE ε4 carriers who survive to advanced age develop Alzheimer's disease (AD); factors attenuating the risk of ε4 on AD may exist. Guided by the top ε4-attenuating signals from methylome-wide association analyses (N=572, ε4+ and ε4-) of neurofibrillary tangles and neuritic plaques, we conducted a meta-analysis for pathological AD within the ε4+ subgroups (N=235) across four independent collections of...

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Identifiers

PMID: 34393677
DOI: 10.1002/alz.043533
PMCID: PMC8362904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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