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Article

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2022

Ma Yiyi, Yu Lei, Olah Marta, Smith Rebecca, Oatman Stephanie R, Allen Mariet, Pishva Ehsan, Zhang Bin, Menon Vilas, Ertekin-Taner Nilüfer, Lunnon Katie, Bennett David A, Klein Hans-Ulrich, De Jager Philip L

Abstract excerpt

Not all apolipoprotein E (APOE) ε4 carriers who survive to advanced age develop Alzheimer's disease (AD); factors attenuating the risk of ε4 on AD may exist. Guided by the top ε4-attenuating signals from methylome-wide association analyses (N = 572, ε4+ and ε4-) of neurofibrillary tangles and neuritic plaques, we conducted a meta-analysis for pathological AD within the ε4+ subgroups (N = 235) across four...

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Identifiers

PMID: 34482628
DOI: 10.1002/alz.12425
PMCID: PMC9475136

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Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans.PMID 34482628Read ↗

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