Article
RNASE6 is a novel modifier of APOE-ε4 effects on cognition.
Neurobiology of aging - 1 Oct 2022
Seto Mabel, Weiner Rebecca L, Dumitrescu Logan, Mahoney Emily R, Hansen Shania L, Janve Vaibhav, Khan Omair A, Liu Dandan, Wang Yanling, Menon Vilas, De Jager Philip L, Schneider Julie A, Bennett David A, Gifford Katherine A, Jefferson Angela L, Hohman Timothy J
Abstract excerpt
Apolipoprotein E4 (APOE-ε4), the strongest common genetic risk factor for Alzheimer's disease (AD), contributes to worse cognition in older adults. However, many APOE-ε4 carriers remain cognitively normal throughout life, suggesting that neuroprotective factors may be present in these individuals. In this study, we leverage whole-blood RNA sequencing (RNAseq) from 324 older adults to identify genetic modifiers of...
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