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Article

Reconstituting human somitogenesis in vitro.

Nature - 1 Feb 2023

Yamanaka Yoshihiro, Hamidi Sofiane, Yoshioka-Kobayashi Kumiko, Munira Sirajam, Sunadome Kazunori, Zhang Yi, Kurokawa Yuzuru, Ericsson Rolf, Mieda Ai, Thompson Jamie L, Kerwin Janet, Lisgo Steven, Yamamoto Takuya, Moris Naomi, Martinez-Arias Alfonso, Tsujimura Taro, Alev Cantas

Abstract excerpt

The segmented body plan of vertebrates is established during somitogenesis, a well-studied process in model organisms; however, the details of this process in humans remain largely unknown owing to ethical and technical limitations. Despite recent advances with pluripotent stem cell-based approaches1-5, models that robustly recapitulate human somitogenesis in both space and time remain scarce. Here we introduce a...

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Identifiers

PMID: 36543322
DOI: 10.1038/s41586-022-05649-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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