Article

Machine learning directed organoid morphogenesis uncovers an excitable system driving human axial elongation

2022-05-11

Abstract excerpt

<h4>Summary</h4> The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the embryo elongates along this axis, progenitors in the tailbud give rise to axial tissues that generate the spinal cord, skeleton, and musculature. The mechanisms underlying human axial elongation are unknown. While ethics necessitate in vitro studies, the variability of human organoid systems has hindered mec...

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Literature Corpus work: d13ebf9e-7d42-5470-b3aa-cd782b9ed69f
DOI: 10.1101/2022.05.10.491358

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