Article

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and disease

2025-12-22

Abstract excerpt

<h4>Summary</h4> Human embryoid models enable mechanistic studies of development and disease. We generated trunk embryoids from human pluripotent stem cells that recapitulate posterior trunk formation at Carnegie stage (CS) 8-10, with patterned anterior-posterior (A-P) and dorsal-ventral (D-V) axes. These self-organizing structures comprise a ventral notochord, dorsal neural tube, floor plate and bilateral somite...

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Literature Corpus work: 8a7d0733-8b45-5ee2-8622-4f0b1e9b3a73
DOI: 10.64898/2025.12.20.695666

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