Article

Cryptic Promoter Activation Drives <i>POU5F1</i> ( <i>OCT4</i> ) Expression in Renal Cell Carcinoma

2018-07-27

Abstract excerpt

Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. As a model system, we used renal cell carcinoma (RCC), the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. We performed genome-wide chromatin accessibility and transcriptome profiling on paired tumor/normal samples and found that n...

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Literature Corpus work: 170001a4-c93f-5b24-bdf7-e834a1e4d5d8
DOI: 10.1101/379198

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