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Epigenomic charting and functional annotation of risk loci in renal cell carcinoma

21 Jan 2023

Abstract excerpt

While the mutational and transcriptional landscapes of renal cell carcinoma (RCC) are well-known, the epigenome is poorly understood. We characterize the epigenome of clear cell (ccRCC), papillary (pRCC), and chromophobe RCC (chRCC) by using ChIP-seq, ATAC-Seq, RNA-seq, and SNP arrays. We integrate 153 individual data sets from 42 patients and nominate 50 histology-specific master transcription factors (MTF) to...

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PMID: 36681680
DOI: 10.1038/s41467-023-35833-5

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