The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.

doi:10.1038/s41586-022-04809-8

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Article

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.

Nature - 1 Jun 2022

Patel Saroor A, Hirosue Shoko, Rodrigues Paulo, Vojtasova Erika, Richardson Emma K, Ge Jianfeng, Syafruddin Saiful E, Speed Alyson, Papachristou Evangelia K, Baker David, Clarke David, Purvis Stephenie, Wesolowski Ludovic, Dyas Anna, Castillon Leticia, Caraffini Veronica, Bihary Dóra, Yong Cissy, Harrison David J, Stewart Grant D, Machiela Mitchell J, Purdue Mark P, Chanock Stephen J, Warren Anne Y, Samarajiwa Shamith A, Carroll Jason S, Vanharanta Sakari

Abstract excerpt

Large-scale human genetic data1-3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrate that the lineage transcription factor paired box 8 (PAX8) is required for oncogenic signalling by two common genetic alterations that cause clear cell renal cell...

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PMID: 35676472
DOI: 10.1038/s41586-022-04809-8
PMCID: PMC9242860

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