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Article

Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma

1 Mar 2019

Abstract excerpt

BACKGROUND: Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive study, novel therapeutic strategies to target RCC have been difficult to develop. Since the RCC epigenome is...

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Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation
Share to Renal cell carcinoma treatment

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PMID: 30827930
DOI: 10.1016/j.ebiom.2019.01.063

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