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Article

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

PLoS genetics - 1 Jul 2017

Grampp Steffen, Schmid Virginia, Salama Rafik, Lauer Victoria, Kranz Franziska, Platt James L, Smythies James, Choudhry Hani, Goppelt-Struebe Margarete, Ratcliffe Peter J, Mole David R, Schödel Johannes

Abstract excerpt

Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of genetic signals on this pathway, we aligned human RCC-susceptibility polymorphisms with genome-wide assays of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28715484
DOI: 10.1371/journal.pgen.1006872
PMCID: PMC5536434

Genes

BHLHE41

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Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.PMID 28715484Read ↗

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