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Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition

9 Feb 2024

Abstract excerpt

During kidney development, nephron epithelia arise de novo from fate-committed mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET). Downstream of fate specification, transcriptional mechanisms that drive establishment of epithelial morphology are poorly understood. We used human iPSC-derived renal organoids, which recapitulate nephrogenesis, to investigate mechanisms controlling renal...

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Genetic and Kidney Cyst Diseases
Renal and related cancers
Renal cell carcinoma treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38340720
DOI: 10.1016/j.devcel.2024.01.011

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