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Article

The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression.

The Journal of biological chemistry - 1 Mar 2022

Protze Johanna, Naas Stephanie, Krüger René, Stöhr Christine, Kraus Andre, Grampp Steffen, Wiesener Michael, Schiffer Mario, Hartmann Arndt, Wullich Bernd, Schödel Johannes

Abstract excerpt

Evolution of clear cell renal cell carcinoma is guided by dysregulation of hypoxia-inducible transcription factor (HIF) pathways following loss of the von Hippel-Lindau tumor suppressor protein. Renal cell carcinoma (RCC)-associated polymorphisms influence HIF-DNA interactions at enhancers of important oncogenes thereby modulating the risk of developing renal cancer. A strong signal of genome-wide association...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 14

Share to Gene Expression Regulation, Neoplastic

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Identifiers

PMID: 35148991
DOI: 10.1016/j.jbc.2022.101699
PMCID: PMC8897700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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