Article

An integrative single-cell and multi-omics analysis identifies an ATF4-centered basal malignant state associated with endothelial signaling and immunotherapy outcomes in clear cell renal cell carcinoma

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>Background Clear cell renal cell carcinoma (ccRCC) is characterized by malignant-cell heterogeneity and extensive tumor–microenvironment interactions. However, tumor-intrinsic regulatory states connected to specific microenvironmental ligand inputs remain incompletely defined. Methods We performed an integrative analysis of publicly available ccRCC datasets. Single-cell RNA-seq data f...

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Literature Corpus work: af581b52-1abf-54e6-a451-7a62f60955a0
DOI: 10.21203/rs.3.rs-9686678/v1

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