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Article

Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes

1 Aug 2017

Abstract excerpt

Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between samples. This...

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PMID: 28793269
DOI: 10.1016/j.celrep.2017.07.043

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