Article

Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transition

2023-04-30

Abstract excerpt

<h4>Summary</h4> During kidney development, nephron epithelia arise de novo from fate-committed mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET). Downstream of fate specification, transcriptional mechanisms that drive establishment of epithelial morphology through MET are poorly understood. We used human renal organoids derived from induced pluripotent stem cells, which recapitulate n...

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Literature Corpus work: d0d84008-3ff9-5317-a6fb-f8b2bf68a6bf
DOI: 10.1101/2023.04.30.538857

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