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Article

Deciphering the peripheral immune landscape of Alzheimer's disease through integrated multi-omics research and cohort validation.

Frontiers in immunology - 1 Jan 2026

Lv Shi, Kuang Jin-Yi, Wang Tian-Wei, Zhang Li-Ping, Liu Jian, Wang Wen-di, Yang Ming-Feng, Ni Qing-Bin, Sun Bao-Liang, Sun Jing-Yi

Abstract excerpt

Objective: This study investigated molecular drivers of AD-associated peripheral immune dysregulation to identify pathogenic genes and therapeutic targets for precision diagnosis and intervention. Methods: A large-scale GWAS meta-analysis (n = 894,710) was performed, followed by two-sample Mendelian randomization (MR) using multi-tissue cis-eQTL data to identify putative causal genes. Immune response differential...

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Source

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Identifiers

PMID: 42051535
DOI: 10.3389/fimmu.2026.1648591
PMCID: PMC13111265

Genes

PLEKHA1
PTK2B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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