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Article

Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence.

Molecular psychiatry - 1 Aug 2024

Enduru Nitesh, Fernandes Brisa S, Bahrami Shahram, Dai Yulin, Andreassen Ole A, Zhao Zhongming

Abstract excerpt

The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been observed in both epidemiological and molecular studies, suggesting a neuroinflammatory basis in AD. However, their shared genetic components have not been systematically studied. Here, we composed an atlas of the shared genetic associations between 11 immune-mediated diseases and AD by analyzing genome-wide association studies...

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Source

Identifiers

PMID: 38499654
DOI: 10.1038/s41380-024-02510-y

Genes

ABCB9
ADAMTS4
DHODH
FUT2
GRAMD1B
HBEGF
TNIP1
TSPAN14
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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