Article

Analysis of human immunoglobulin VDJ and DJ rearrangements shows N region synthesis by concatenation of cytosine-rich strands preferentially originating from trimmed germline gene segments

2018-01-23

Abstract excerpt

The formation of non-templated (N) regions during immunoglobulin gene rearrangement is a major contributor to antibody diversity. To gain insights into the mechanisms behind this, we studied the nucleotide composition of N regions within 29,962 unique human V H DJ H -rearrangements and 8,728 unique human DJ H -rearrangements containing exactly one identifiable D-gene segment and thus two N regions, N1 and N2. W...

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Literature Corpus work: 15d0dfb4-7281-57eb-8800-1e0ec1b48198
DOI: 10.1101/248021

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