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Article

Both DNA strands of antibody genes are hypermutation targets.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998

Milstein C, Neuberger M S, Staden R

Abstract excerpt

During the maturation of the immune response, antibody genes are subjected to localized hypermutation. Mutations are not evenly distributed along the V gene; intrinsic hot spots exist that are correlated with primary sequence motifs. Although the mechanism of hypermutation remains unknown, it has been proposed to exhibit DNA strand polarity because purine residues on the coding strand are more frequently targeted...

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Identifiers

PMID: 9671757
DOI: 10.1073/pnas.95.15.8791
PMCID: PMC21155

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