Article
Exonuclease activity and P nucleotide addition in the generation of the expressed immunoglobulin repertoire.
BMC immunology - 2 Sept 2004
Jackson Katherine J L, Gaeta Bruno, Sewell William, Collins Andrew M
Abstract excerpt
BACKGROUND: Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. Two such processes are the loss of nucleotides through the action of unknown exonuclease(s) and the addition of P nucleotides. The study of such processes has been compromised by difficulties in reliably aligning immunoglobulin genes and in the partitioning of nucleotides between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.