Article
Amino acid insertions and deletions contribute to diversify the human Ig repertoire.
Immunological reviews - 1 Apr 1998
Wilson P, Liu Y J, Banchereau J, Capra J D, Pascual V
Abstract excerpt
The sequence analysis of Ig variable region genes transcribed within different B-cell subpopulations from human tonsil led us to identify a rare DNA sequence modification event consisting of bp insertions and/or deletions (I/D). Although these events were previously reported, they had never been...
Topics
- Amino Acid Substitution
- Antibody Diversity
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Sequence Deletion