The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire.

doi:10.1111/j.1600-065x.1998.tb01435.x

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Article

The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire.

Immunological reviews - 1 Apr 1998

Blanden R V, Rothenfluh H S, Zylstra P, Weiller G F, Steele E J

Abstract excerpt

We present here a unifying hypothesis for the molecular mechanism of somatic hypermutation and somatic gene conversion in IgV genes involving reverse transcription using RNA templates from the V-gene loci to produce cDNA which undergoes homologous recombination with chromosomal V(D)J DNA. Experim...

Topics

Animals
Antibody Diversity
Cell Division
Evolution, Molecular
Gene Conversion
Gene Rearrangement
Germ-Line Mutation
Humans
Immunoglobulin Variable Region
Models, Genetic
Mutation

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