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Article

Tandem Substitutions in Somatic Hypermutation.

Frontiers in immunology - 1 Jan 2021

Sepúlveda-Yáñez Julieta H, Alvarez Saravia Diego, Pilzecker Bas, van Schouwenburg Pauline A, van den Burg Mirjam, Veelken Hendrik, Navarrete Marcelo A, Jacobs Heinz, Koning Marvyn T

Abstract excerpt

Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but tandem substitutions may also occur. We investigated incidence and sequence context of tandem substitutions by massive parallel sequencing of V(D)J repertoires in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35069591
DOI: 10.3389/fimmu.2021.807015
PMCID: PMC8781386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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