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Article

The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.

Annual review of biochemistry - 20 Jun 2021

Compe Emmanuel, Egly Jean-Marc

Abstract excerpt

In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by regulatory elements called enhancers, which are recognized by specific DNA-binding transcription factors that recruit cofactors and convey, following chromatin remodeling, the...

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Identifiers

PMID: 34153211
DOI: 10.1146/annurev-biochem-090220-112253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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