Article

Multiplexed dissection of a model human transcription factor binding site architecture

2019-05-02

Abstract excerpt

In eukaryotes, transcription factors orchestrate gene expression by binding to TF-Binding Sites (TFBSs) and localizing transcriptional co-regulators and RNA Polymerase II to cis-regulatory elements. The strength and regulation of transcription can be modulated by a variety of factors including TFBS composition, TFBS affinity and number, distance between TFBSs, distance of TFBSs to transcription start sites, and ep...

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Literature Corpus work: 6b257c83-acb3-5ba7-ae2e-f3a6835018b2
DOI: 10.1101/625434

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