Article

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.

2026-03-26

Abstract excerpt

<h4>Background: </h4> Lactamase B (LACTB) is a mitochondrial protease associated with cancer progression and lipid metabolism. LACTB is located in an AD locus and has been associated with Alzheimers Disease (AD) in a proteomic study. <h4>Methods:</h4> We performed Mendelian randomization (MR) to evaluate the relationship between LACTB expression, succinyl-carnitine, and AD risk. We generated LACTB knock-down (KD)...

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Literature Corpus work: 14431a2e-32db-5ceb-92ab-5af4303573c2
DOI: 10.64898/2026.03.24.711053

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Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.DOI 10.64898/2026.03.24.711053Read

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