Article

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer’s disease risk

2026-07-13

Abstract excerpt

<title>Abstract</title> <p> Lactamase β (LACTB) is a serine β-lactamase-like mitochondrial enzyme genetically associated with obesity, kidney disease, and hyperlipidemia. <italic>LACTB</italic> is located in an Alzheimer’s Disease (AD) risk locus and its expression in the brain has been genetically associated with AD susceptibility. The aim of this study was to investigate LACTB function and genetic link to AD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e39f51b7-ca2e-524d-b7cc-7453dad59c29
DOI: 10.21203/rs.3.rs-10216155/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine and reduced Alzheimer’s disease riskDOI 10.21203/rs.3.rs-10216155/v1Read

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.Semantic proximity Read

Knockout of Perilipin-2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer’s Disease StimuliSemantic proximity Read

LACTB, a Metabolic Therapeutic Target in Clinical Cancer ApplicationSemantic proximity Read

Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS DiseasesSemantic proximity Read

Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.Semantic proximity Read

Comparative Enzymatic Profiling of Enteric vs. Cortical Neural Stem Cells: Establishing a Methodological Foundation for Modeling Enteric NeurodegenerationSemantic proximity Read

Insight into the roles of lactylation in macrophages: functions and clinical implicationsSemantic proximity Read

Pyruvate Kinase Isoenzyme M2 Impairs Cognition in Systemic Lupus Erythematosus by Promoting Microglial Synaptic Pruning via β-Catenin Signaling PathwaySemantic proximity Read

Impact of Klotho Genotype on Lactylation in Alzheimer’s Disease and Mechanistic InsightsSemantic proximity Read

Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 HyperactivationSemantic proximity Read

Targeting succinate-driven microglial metabolic reprogramming alleviates neuroinflammation after cerebral ischemia–reperfusionSemantic proximity Read

Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted MedicineSemantic proximity Read