Article

Alzheimer’s disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism

2023-04-07

Abstract excerpt

<h4>Introduction</h4> Neuroinflammation and metabolic dysfunction are early alterations in Alzheimer’s disease brain that are thought to contribute to disease onset and progression. Glial activation due to protein deposition results in cytokine secretion and shifts in brain metabolism, which have been observed in Alzheimer’s disease patients. However, the mechanism by which this immunometabolic feedback loop can...

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Literature Corpus work: 52b60eb3-03a5-5e49-8016-55eed02b9527
DOI: 10.1101/2023.04.07.536014

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