Article

Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis

2025-10-25

Abstract excerpt

<title>Abstract</title> <p> Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited therapeutic options. The metabolome comprises small-molecules (typically < 1 kDa) present in biological tissues and fluids, which are the intermediates and end-products of cellular metabolism. The plasma metabolome has been linked to ALS pathogenesis, particularly with respect to energy su...

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Literature Corpus work: f8085d85-01f7-5e0f-be10-67ab4d84e025
DOI: 10.21203/rs.3.rs-7811456/v1

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