Article

Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking

2024-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified many gene polymorphisms associated with an increased risk of developing Late Onset Alzheimer’s Disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing microglia innate immune responses and lipid metabolism. Angiotensin Converting Enzyme (ACE), a GWAS LOAD risk-associated gene best known for its ro...

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Literature Corpus work: 48777909-bcd3-517b-bd1a-bf654fe4bbac
DOI: 10.1101/2024.04.24.590837

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