Article

The therapeutic potential of D-Serine in reducing expression of the cytopathic genotoxin colibactin

2022-03-09

Abstract excerpt

Som e Escherichia coli strains belonging mainly to the B2 phylogroup harbour the pks island, a 54 kb genomic island encoding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chromosomal instability. Moreover, production of colibactin has been implicated in the development of colorectal cancer. In this study, we demonstr...

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Literature Corpus work: 13c5e6d0-129c-5103-b43a-5cc888e4acc0
DOI: 10.1101/2022.03.08.483572

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