Article

Colibactin DNA damage signature indicates causative role in colorectal cancer

2019-10-25

Abstract excerpt

Colibactin, a potent genotoxin of Escherichia coli , causes DNA double strand breaks (DSBs) in human cells. We investigated if colibactin creates a particular DNA damage signature in infected cells by identifying DSBs in colon cells after infection with pks + E.coli . Interestingly, genomic contexts of DSBs were enriched for AT-rich penta-/hexameric sequence motifs, exhibiting a particularly narrow minor groove...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1d17b22-a465-5454-aadd-b0913bc5466d
DOI: 10.1101/819854

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Colibactin DNA damage signature indicates causative role in colorectal cancerDOI 10.1101/819854Read

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.Semantic proximity Read

Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer.Semantic proximity Read

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage.Semantic proximity Read

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.Semantic proximity Read

Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survivalSemantic proximity Read

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavageSemantic proximity Read

Contribution of pks+ Escherichia coli (E. coli) to Colon CarcinogenesisSemantic proximity Read

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.Semantic proximity Read

Colibactin-associated mutations in the human colon appear to reflect anatomy and early exposure, not oncogenesisSemantic proximity Read

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interactionSemantic proximity Read

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patientsSemantic proximity Read

Microbiome-Genome Crosstalk in Colorectal Cancer: Colibactin Signatures and Fusobacterium nucleatum in Epidemiology, Driver Selection, and Translation.Semantic proximity Read