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Article

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917.

mSphere - 25 Aug 2021

Nougayrède Jean-Philippe, Chagneau Camille V, Motta Jean-Paul, Bossuet-Greif Nadège, Belloy Marcy, Taieb Frédéric, Gratadoux Jean-Jacques, Thomas Muriel, Langella Philippe, Oswald Eric

Abstract excerpt

The probiotic Escherichia coli strain Nissle 1917 (DSM 6601, Mutaflor), generally considered beneficial and safe, has been used for a century to treat various intestinal diseases. However, Nissle 1917 hosts in its genome the pks pathogenicity island that codes for the biosynthesis of the genotoxin colibactin. Colibactin is a potent DNA alkylator, suspected to play a role in colorectal cancer development. We show...

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PMID: 34378987
DOI: 10.1128/mSphere.00624-21
PMCID: PMC8386472

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A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917.PMID 34378987Read ↗

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