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Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?

14 Dec 2021

Abstract excerpt

Colibactin is a genotoxin produced primarily by Escherichia coli harboring the genomic pks island (pks+ E. coli). Pks+ E. coli cause host cell DNA damage, leading to chromosomal instability and gene mutations. The signature of colibactin-induced mutations has been described and found in human colorectal cancer (CRC) genomes. An inflamed intestinal environment drives the expansion of pks+ E. coli and promotes...

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Identifiers

PMID: 34941734
DOI: 10.3390/toxins13120897

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?PMID 34941734Read ↗

Contribution of pks+ Escherichia coli (E. coli) to Colon CarcinogenesisSemantic proximity Read ↗

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin ColibactinSemantic proximity Read ↗

Intestinal Inflammation Targets Cancer-Inducing Activity of the MicrobiotaSemantic proximity Read ↗

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interactionSemantic proximity Read ↗

Programmable conjugative CRISPR interference targeting genotoxin in the gutSemantic proximity Read ↗

Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survivalSemantic proximity Read ↗

Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer.Semantic proximity Read ↗

The Colibactin-Producing <i>Escherichia coli</i> alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistanceSemantic proximity Read ↗

Programmable conjugative CRISPR interference targeting genotoxin in the gutSemantic proximity Read ↗

Targeted depletion of pks+ bacteria from a fecal microbiota using specific antibodies.Semantic proximity Read ↗

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patientsSemantic proximity Read ↗

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.Semantic proximity Read ↗

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