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Article

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.

Neoplasia (New York, N.Y.) - 1 Sept 2023

Dougherty Michael W, Valdés-Mas Rafael, Wernke Kevin M, Gharaibeh Raad Z, Yang Ye, Brant Jason O, Riva Alberto, Muehlbauer Marcus, Elinav Eran, Puschhof Jens, Herzon Seth B, Jobin Christian

Abstract excerpt

Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as "pks" encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature that is also detected in human CRC genomes. Yet, how colibactin exposure affects the mutational landscape of CRC in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37499275
DOI: 10.1016/j.neo.2023.100918
PMCID: PMC10413156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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