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Article

Targeted depletion of pks+ bacteria from a fecal microbiota using specific antibodies.

mSystems - 29 Jun 2023

Blanco-Míguez Aitor, Marcos-Fernández Raquel, Guadamuro-García Lucía, Fdez-Riverola Florentino, Cubiella Joaquín, Lourenço Anália, Margolles Abelardo, Sánchez Borja

Abstract excerpt

The pks island is one of the most prevalent pathogenicity islands among the Escherichia coli strains that colonize the colon of colorectal carcinoma (CRC) patients. This pathogenic island encodes the production of a nonribosomal polyketide-peptide named colibactin, which induces double-strand breaks in DNA molecules. Detection or even depletion of this pks-producing bacteria could help to understand the role of...

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Identifiers

PMID: 37219498
DOI: 10.1128/msystems.00079-23
PMCID: PMC10308883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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