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Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population.

Microbial genomics - 1 May 2021

Auvray Frédéric, Perrat Alexandre, Arimizu Yoko, Chagneau Camille V, Bossuet-Greif Nadège, Massip Clémence, Brugère Hubert, Nougayrède Jean-Philippe, Hayashi Tetsuya, Branchu Priscilla, Ogura Yoshitoshi, Oswald Eric

Abstract excerpt

The pks island codes for the enzymes necessary for synthesis of the genotoxin colibactin, which contributes to the virulence of Escherichia coli strains and is suspected of promoting colorectal cancer. From a collection of 785 human and bovine E. coli isolates, we identified 109 strains carrying a highly conserved pks island, mostly from phylogroup B2, but also from phylogroups A, B1 and D. Different scenarios of...

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Identifiers

PMID: 33961542
DOI: 10.1099/mgen.0.000579
PMCID: PMC8209727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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