Article

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

2019-01-24

Abstract excerpt

Colibactin is an as-yet-uncharacterized human gut bacterial genotoxin, whose biosynthesis is linked to clb genomic island that distributes widespread in pathogenic and commensal human enterobacteria. Colibactin-producing gut microbes promote colon tumor formation and enhance progression of colorectal cancer (CRC) via DNA double-strand breaks (DSBs)-induced cellular senescence and death; however, the chemical basi...

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Literature Corpus work: dbface96-0c3a-5288-ba65-501dd01cfe8b
DOI: 10.1101/530204

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