Article

Disruption of Proteoglycan 4 (PRG4)-CD44 Signaling Modulates Chronic Synovitis in Conditionally Inactivated Mice

2025-10-17

Abstract excerpt

<title>Abstract</title> <p> Background Proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. PRG4 inhibits synovial macrophage (SM) activation <italic>via</italic> xanthine oxidase (XO) and hypoxia inducible factor alpha (HIF-1α) suppression. We aimed to evaluate the contribution of PRG4-CD44 interaction to synovial homeostasis and investigate PRG4...

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Literature Corpus work: 13be861b-6f97-5908-a33b-d235f002cf77
DOI: 10.21203/rs.3.rs-7659196/v1

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