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Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies

12 Mar 2025

Abstract excerpt

Proteoglycan 4 (PRG4), also known as lubricin, plays a critical role in maintaining joint homeostasis by reducing friction between articular cartilage surfaces and preventing cartilage degradation. Its deficiency leads to early-onset osteoarthritis (OA), while overexpression can protect against cartilage degeneration. Beyond its lubricating properties, PRG4 exerts anti-inflammatory effects by interacting with...

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PMID: 40149669
DOI: 10.3390/biomedicines13030693

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