Article
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Arthritis research & therapy - 9 Nov 2023
Guo Dong, Pan Haoyan, Lu Xueying, Chen Zhong, Zhou Laixi, Chen Shuxin, Huang Jin, Liang Xinzhi, Xiao Zhisheng, Zeng Hua, Shao Yan, Qi Weizhong, Xie Denghui, Lin Chuangxin
Abstract excerpt
BACKGROUND: The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerbation of rheumatoid arthritis (RA) through the promotion of synovitis and cartilage damage. Regrettably, there is currently no effective therapeutic intervention available to address this issue. Recent research has shed light on the crucial regulatory role of R-spondin-2 (Rspo2) in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.