Article

Loss of <i>Grem1</i> -articular cartilage progenitor cells causes osteoarthritis

2023-03-30

Abstract excerpt

<h4>SUMMARY</h4> Osteoarthritis (OA), which carries an enormous disease burden across the world, is characterised by irreversible degeneration of articular cartilage (AC), and subsequently bone. The cellular cause of OA is unknown. Here, using lineage tracing in mice, we show that the BMP-antagonist Gremlin 1 ( Grem1 ) marks a novel chondrogenic progenitor (CP) cell population in the articular surface that gene...

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Literature Corpus work: f456d7e6-0291-5422-8e51-0cafd0c995ab
DOI: 10.1101/2023.03.29.534651

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