Article

Proteoglycan 4 (Lubricin) and Regulation of Xanthine Oxidase in Synovial Macrophage as A Mechanism of Controlling Synovitis

2024-09-17

Abstract excerpt

<title>Abstract</title> <p>Background Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis. Proteoglycan 4 (PRG4) is a mucinous glycoprotein that fulfills lubricating and homeostatic roles in the...

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Literature Corpus work: 35885afd-0902-5092-b7e1-090af80b40fe
DOI: 10.21203/rs.3.rs-4934175/v1

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