Article

Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

2023-11-20

Abstract excerpt

<title>Abstract</title> <p>Osteoarthritis (OA) is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat OA. These attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in synovium. In this study, we found that phosphoglycerate mutase 5 (PGA...

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Literature Corpus work: a19f613f-bc40-5b0b-a566-d4d3a44e1228
DOI: 10.21203/rs.3.rs-3566658/v1

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