Article

Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes.

2021-02-01

Abstract excerpt

<h4>Background: </h4> The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate. However, its functional roles in OA still remain undefined. Here, we explored the effects of Vangl2 on OA chondrocyte in vitro, and further elucidated...

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Literature Corpus work: d66a2c75-ac7f-5f09-9ac4-23244e054d87
DOI: 10.21203/rs.3.rs-122627/v2

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