Article

Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells

2022-06-03

Abstract excerpt

<h4>Background: </h4> Lubricin, a proteoglycan encoded by the PRG4 gene, is synthesised by superficial zone (SFZ) chondrocytes and synovial cells. It reduces friction between joints and allows the smooth sliding of tendons. Although lubricin has been shown to be effective against osteoarthritis and synovitis in animals, its clinical application remains untested. In this study, we aimed to induce lubricin-expressin...

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Literature Corpus work: dd34a901-20fa-57ac-9e56-55b9dd60b458
DOI: 10.21203/rs.3.rs-1400781/v2

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